Giles Thomas: ResolverOne, Combining a Spreadsheet with a Programming Language

is a Power User's spreadsheet written in IronPython and DLR that dynamically generates IronPython code based on spreadsheet values and formulas.* The cool thing is you can write .NET code with IronPython (or call .NET code written in any language) directly inline and have it apply to your spreadsheet.

Resolver One has a non-commercial license that you can use to play with and experiment with Iron Python.